The autophagy-inhibitory tissue hormone DBI/ACBP is essential for glucocorticoid-induced immunosuppression.

May 3, 2026

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Key Points

This research aims to dissect the signaling pathway by which glucocorticoids induce immunosuppression, focusing on the role of the hormone DBI/ACBP.
Investigation of glucocorticoid effects on dendritic cells' antigen presentation capacity
Analysis of signaling pathways involving DBI/ACBP
Assessment of DBI/ACBP's role as an autophagy inhibitor
Upregulation of TSC22D3 in dendritic cells following glucocorticoid treatment, leading to reduced antigen presentation
DBI/ACBP acts through a receptor mechanism rather than direct glucocorticoid receptor action
Inhibition of autophagy by DBI/ACBP is essential for mediating glucocorticoid-induced effects.

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Uncovers the mechanism of glucocorticoid-induced immunosuppression in dendritic cells, suggesting a role for DBI/ACBP.

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Shen et al. (2026) studied this question.

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