Juvenile obesity and type 1 diabetes were associated with significantly elevated serum hs-CRP and increased carotid intima-media thickness compared to healthy controls (p<0.0001).
Cross-Sectional (n=376)
Are juvenile obesity and type 1 diabetes associated with low-grade inflammation and early signs of atherosclerosis compared to healthy controls?
Juvenile obesity and type 1 diabetes are associated with significant low-grade inflammation and increased carotid intima-media thickness, suggesting early atherosclerotic changes.
p-value: p=<0.0001
BACKGROUND: Subclinical inflammation has been implicated in the initiation and/or progression of atherosclerosis. Diabetes mellitus and obesity are risk factors for atherosclerosis, and asymptomatic low grade inflammation occurs prior to overt vascular lesions in these patients. In contrast to adults, little information exists concerning low grade inflammation in young type 1 diabetes and juvenile obesity. AIM: To investigate low grade inflammation and immune activation in juvenile diabetes mellitus and obesity. METHODS: hs-CRP, soluble interleukin-2 receptor (sIL-2R), C-peptide, insulin, cortisol, vitamin B12, folic acid, leptin, and homocysteine were determined in 148 patients with juvenile type 1 diabetes, 86 obese children and 142 normal weighted age-matched healthy controls. Intima-media thickness (IMT) and lumen diameter of both common carotid arteries (CCA) was measured by ultrasonography in 52 healthy pediatric controls, 10 diabetics, and 34 obese juveniles. RESULTS: Serum hs-CRP was significantly elevated in patients with type 1 diabetes (p < 0.0001), and obese children (p < 0.0001) as compared to the control group. The obese juveniles (p < 0.0001) and the diabetics (p < 0.0001) showed significantly increased values for IMT of CAAs. Levels of homocysteine, sIL-2R, insulin, cortisol, vitamin B12, and folic acid did not differ from the controls. The elevation of hs-CRP was more pronounced in obesity as compared to type 1 diabetes (p < 0.0001), and the hs-CRP values correlated significantly with body mass index standard deviation score (BMI-SDS) values. Furthermore, the IMT and the luminal diameter of CCAs showed significant correlations with BMI-SDS values. CONCLUSION: A low grade inflammation as determined by serum hs-CRP is significantly increased in children with type 1 diabetes, and even more pronounced in apparently healthy juveniles with obesity. The increased IMT of CCAs strongly argues for an association between this low grade inflammation and early atherosclerotic vessel injury.
Mangge et al. (Wed,) conducted a cross-sectional in Juvenile obesity and Type 1 Diabetes (n=376). Type 1 diabetes and obesity vs. Normal weighted age-matched healthy controls was evaluated on Serum hs-CRP and Intima-media thickness (IMT) (p=<0.0001). Juvenile obesity and type 1 diabetes were associated with significantly elevated serum hs-CRP and increased carotid intima-media thickness compared to healthy controls (p<0.0001).