Low Grade Inflammation in Juvenile Obesity and Type 1 Diabetes Associated with Early Signs of Atherosclerosis
Key result
Juvenile obesity and type 1 diabetes were associated with significantly elevated serum hs-CRP and increased carotid intima-media thickness compared to healthy controls (p<0.0001).
Why the study?
Are juvenile obesity and type 1 diabetes associated with low-grade inflammation and early signs of atherosclerosis compared to healthy controls?
Population
376 juveniles, including 148 with type 1 diabetes, 86 with obesity, and 142 normal-weight age-matched…
Design
Cross-sectional
Authors
Discussion
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Implication
May warrant early CV monitoring in affected youth; leaves open causal links and intervention effects.
Study Design
Type
Cross-Sectional (n=376)
Structured PICO
Are juvenile obesity and type 1 diabetes associated with low-grade inflammation and early signs of atherosclerosis compared to healthy controls?
P
Population
376 juveniles, including 148 with type 1 diabetes, 86 with obesity, and 142 healthy controls, assessed for low-grade inflammation and early signs of atherosclerosis.
C
Comparator
Normal-weight age-matched healthy controls
O
Outcome
Serum hs-CRP levels and Intima-media thickness (IMT) of common carotid arteriessurrogate
Main Result
p-value: p=<0.0001
Juvenile obesity and type 1 diabetes are associated with significant low-grade inflammation and increased carotid intima-media thickness, suggesting early atherosclerotic changes.
Cite This Study
Mangge et al. (2004) conducted a cross-sectional in Juvenile obesity and Type 1 Diabetes (n=376). Type 1 diabetes and obesity vs. Normal weighted age-matched healthy controls was evaluated on Serum hs-CRP and Intima-media thickness (IMT) (p=<0.0001). Juvenile obesity and type 1 diabetes were associated with significantly elevated serum hs-CRP and increased carotid intima-media thickness compared to healthy controls (p<0.0001).