Right bundle branch block was associated with an increased risk of all-cause mortality in the general population (HR 1.17; 95% CI 1.03-1.33) compared with no bundle branch block.
Meta-Analysis (n=201,437)
Does right bundle branch block increase the risk of mortality and cardiovascular events in the general population and patients with heart disease?
Right bundle branch block is a significant prognostic marker associated with increased mortality risk in both the general population and patients with underlying heart disease.
Hazard Ratio: 1.17 (95% CI 1.03–1.33)
BACKGROUND: The prognostic significance of right bundle branch block (RBBB) is inconsistent across studies. We aimed to assess the association between RBBB (in general population and patients with heart disease) and risk of all-cause mortality, cardiac death, acute myocardial infarction (MI), and heart failure (HF). HYPOTHESIS: RBBB may be associated with increased risk of death. METHODS: PubMed, EMBASE, and the Cochrane Library up to February 2015 were searched for prospective cohort studies that reported RBBB at baseline and all-cause mortality, cardiac death, MI, and HF at follow-up. A meta-analysis of published data was undertaken primarily by means of fixed-effects models. RESULTS: Nineteen cohort studies including 201 437 participants were included with a mean follow-up period ranging from 1 to 246 months. For general population with RBBB, the pooled adjusted hazard ratio (HR) for all-cause mortality was 1.17 (95% confidence interval CI: 1.03-1.33) compared with no BBB. General population with RBBB had an increased risk of cardiac death (HR: 1.43, 95% CI: 1.17-1.74). For patients with RBBB and acute MI, the pooled risk ratio was 2.31 (95% CI: 2.13-2.49) for in-hospital mortality, 2.85 (95% CI: 2.46-3.30) for 30-day mortality, and 1.96 (95% CI: 1.59-2.42) for longer-term mortality. For acute HF patients, the pooled risk ratio of all-cause mortality was 1.11 (95% CI: 1.06-1.16), and for chronic HF patients it was 1.75 (95% CI: 1.38-2.22). CONCLUSIONS: Right bundle branch block is associated with an increased risk of mortality in general population and patients with heart disease.
Xiong et al. (Thu,) conducted a meta-analysis in General population and patients with heart disease (n=201,437). Right bundle branch block (RBBB) vs. No bundle branch block was evaluated on All-cause mortality in the general population (HR 1.17, 95% CI 1.03-1.33). Right bundle branch block was associated with an increased risk of all-cause mortality in the general population (HR 1.17; 95% CI 1.03-1.33) compared with no bundle branch block.