1075-OR: Gestational Diabetes Mellitus (GDM), Cord Blood Metabolomics, and Random Plasma Insulin Levels in Childhood

Introduction and Objective: We aimed to identify cord blood metabolomic signatures of GDM and their associations with childhood insulin levels. Methods: We studied 943 mother-child dyads from the Boston Birth Cohort. We ascertained GDM via ICD codes, medication history, and plasma glucose profiles and excluded women with pregestational diabetes mellitus. We measured 378 metabolites in cord blood and random plasma insulin levels in childhood (median IQR: 1.34 y 0.84-3.10). We identified metabolites associated with GDM using linear regression with False Discovery Rate (FDR) correction (FDR 0.05). In children with insulin data (n = 401), we examined associations between cord blood metabolites and childhood insulin using linear regression. We adjusted for covariates listed in the Figure Footnote. Results: Among 943 women (58% Black, 24% Hispanic; 9% with GDM), GDM was associated with alterations in 32 cord blood metabolites spanning 13 classes, including higher diacylglycerol (DAG) and triacylglycerol (TAG) metabolites, and lower cholesteryl ester (CE) and phospholipid (PC, PE) metabolites (Panel A). In the subset, TAGs and DAGs were associated with higher childhood insulin levels, while CE and PE were associated with lower insulin levels (Panel B). Conclusion: Fetal lipid dysregulation may underlie the intergenerational transmission of cardiometabolic risk. Further work should investigate the long-term prognostic significance of these metabolites. Disclosure B. Grobman: None. G. Wang: None. X. Hong: None. L.H. Ngo: None. S. Juraschek: None. X. Wang: None. M. Zhang: None. Funding American Diabetes Association (7-24-ICTSWH-10)