What question did this study set out to answer?

This research aims to identify metabolomic signatures in cord blood related to gestational diabetes mellitus (GDM) and their association with insulin levels in childhood.

June 7, 2026Diabetes

1075-OR: Gestational Diabetes Mellitus (GDM), Cord Blood Metabolomics, and Random Plasma Insulin Levels in Childhood

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This research aims to identify metabolomic signatures in cord blood related to gestational diabetes mellitus (GDM) and their association with insulin levels in childhood.
Studied 943 mother-child dyads from the Boston Birth Cohort.
Measured 378 metabolites in cord blood and assessed random plasma insulin levels in children.
Used linear regression with FDR correction to analyze associations and adjusted for specified covariates.
GDM was associated with changes in 32 cord blood metabolites, including increased diacylglycerol and triacylglycerol, and decreased cholesteryl ester and phospholipid levels.
In children, higher levels of TAGs and DAGs correlated with increased insulin levels, while lower levels of CE and PE were linked to decreased insulin levels.

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Implication

Randomized trial identifies metabolomic associations with insulin levels in children of mothers with GDM, suggesting intergenerational cardiometabolic risk implications.

Cite This Study

Grobman et al. (2026) studied this question.

synapsesocial.com/papers/6a250c027def13d035e1bfe5 https://doi.org/10.2337/db26-1075-or

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Implication

Randomized trial identifies metabolomic associations with insulin levels in children of mothers with GDM, suggesting intergenerational cardiometabolic risk implications.

1075-OR: Gestational Diabetes Mellitus (GDM), Cord Blood Metabolomics, and Random Plasma Insulin Levels in Childhood

Key Points

Discussion

Implication

Cite This Study

1075-OR: Gestational Diabetes Mellitus (GDM), Cord Blood Metabolomics, and Random Plasma Insulin Levels in Childhood

Key Points

Discussion

Implication

Cite This Study

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