June 14, 2024Diabetes

1965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk

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Upregulation of steroid hormone signaling marks the placental transcriptome in gestational diabetes mellitus, with altered nutrient transport pathways.
Elevated cord blood fructosamine concentrations (p < 0.01) accompanied significant upregulation of arachidonic acid and urea cycle pathways in newborns.
Highlights how altered nutrient transport and hormone-driven DNA methylation in the placenta may mechanistically transmit metabolic risk across generations.

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Implication

Comparative study reveals altered placental transcription and cord metabolites in gestational diabetes dyads, suggesting epigenetic pathways for intergenerational metabolic risk.

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Thaker et al. (2024) studied this question.

synapsesocial.com/papers/68e64c4bb6db6435875dd1b9 https://doi.org/10.2337/db24-1965-lb

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Implication

Comparative study reveals altered placental transcription and cord metabolites in gestational diabetes dyads, suggesting epigenetic pathways for intergenerational metabolic risk.

1965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk

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1965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk

Key Points

Discussion

Implication

Cite This Study

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