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The study aims to investigate how maternal obesity and gestational diabetes affect offspring body composition and metabolism.

The association of maternal obesity and gestational diabetes during pregnancy with offspring adiposity and dysmetabolism: the Intergenerational Transmission of Obesity (ITO) study

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The study aims to investigate how maternal obesity and gestational diabetes affect offspring body composition and metabolism.
Prospective cohort study conducted at two U.S. centers
Participants included pregnant individuals in three groups: normal BMI without GDM, obesity without GDM, and GDM
Collected fasting maternal blood, neonatal measurements, and infant body composition at delivery and 3 months
Of 283 enrollees, 278 were analyzed: 95 normal BMI, 104 obesity without GDM, 79 GDM
Neonates from GDM group had higher birthweight and leptin levels
Maternal triglycerides were found to predict neonatal outcomes including birthweight and body measurements

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Prospective cohort study examines metabolic impacts of maternal obesity and GDM on offspring, highlighting implications for maternal health.

Battarbee et al. (2026) studied this question.

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Prospective cohort study examines metabolic impacts of maternal obesity and GDM on offspring, highlighting implications for maternal health.