What question did this study set out to answer?

To characterize gestational diabetes mellitus (GDM)-associated DNA methylation differences in cord blood, evaluate consistency with maternal epigenetic marks, and explore links to neonatal growth outcomes.

August 19, 2026Cardiovascular DiabetologyOpen Access

Cord blood DNA methylation differences associated with gestational diabetes and partial consistency with maternal methylation patterns

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Authors

LTLinares-Pineda TeresaCentre for Biomedical Network Research on Rare Diseases PNPeña-Montero NereaUniversidad Autónoma de Madrid LALendínez-Jurado AlfonsoHospital Regional Universitario de Málaga

Discussion

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Implication

Epigenome-wide association study reveals regional DNA methylation changes in cord blood from gestational diabetes pregnancies, indicating potential intrauterine epigenetic programming.

Key Points

To characterize gestational diabetes mellitus (GDM)-associated DNA methylation differences in cord blood, evaluate consistency with maternal epigenetic marks, and explore links to neonatal growth outcomes.
Conducted an epigenome-wide association study (EWAS) using the Infinium MethylationEPIC BeadChip on cord blood DNA from 22 neonates (11 GDM-exposed and 11 unexposed controls).
Evaluated differentially methylated positions (DMPs) and regions (DMRs) adjusting for fetal sex, gestational age, maternal age, pre-pregnancy BMI, and estimated cell-type proportions, alongside candidate analyses of 272 maternal GDM-associated CpGs.
Identified 17 DMRs significant after FDR correction, including regions annotated to ZFP57 and HIF3A, which enriched for ClinVar pathways related to neonatal and monogenic diabetes.
Found 25 of 272 maternal candidate CpGs showed nominal association in cord blood, with 12 sharing effect direction and weak positive overall correlation; no individual DMP reached FDR-adjusted significance.
Observed nominal associations between cord blood methylation at candidate sites and neonatal birth weight and head circumference percentiles.

Cite This Study

Teresa et al. (2026) studied this question.

synapsesocial.com/papers/6a85638803308d306e2d6c6b https://doi.org/10.1186/s12933-026-03323-9

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Implication

Epigenome-wide association study reveals regional DNA methylation changes in cord blood from gestational diabetes pregnancies, indicating potential intrauterine epigenetic programming.

Cord blood DNA methylation differences associated with gestational diabetes and partial consistency with maternal methylation patterns

Discussion

Member takes

Implication

Key Points

Cite This Study

Cord blood DNA methylation differences associated with gestational diabetes and partial consistency with maternal methylation patterns

Discussion

Member takes

Implication

Key Points

Cite This Study

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