What question did this study set out to answer?

Identify stage-specific maternal DNA methylation signatures associated with gestational diabetes mellitus across pregnancy to elucidate underlying epigenetic and biological mechanisms.

December 24, 2025Journal of Translational MedicineOpen Access

Maternal DNA methylation signatures of gestational diabetes across all stages of pregnancy

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Authors

LSLuma SrourHamad bin Khalifa University YBYosra BejaouiHamad bin Khalifa University JJJayakumar JerobinHamad Medical Corporation

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Implication

Cohort study uncovers trimester-specific DNA methylation signatures and novel risk genes in pregnant women with gestational diabetes, indicating environmental and metabolic epigenetic influences.

Key Points

Identify stage-specific maternal DNA methylation signatures associated with gestational diabetes mellitus across pregnancy to elucidate underlying epigenetic and biological mechanisms.
Conducted genome-wide DNA methylation profiling across all three trimesters in a discovery cohort using the Infinium MethylationEPIC v2.0 BeadChip.
Validated differentially methylated sites in an independent second cohort.
Performed downstream KEGG pathway, Gene Ontology enrichment, trait enrichment, and gene expression regulation analyses on validated sites from the second and third trimesters.
Identified and validated novel differentially methylated CpG sites affecting genes linked to gestational diabetes, including RSL1D1, HOXD4, and MROH6.
Revealed associations between gestational diabetes-specific methylation marks and downstream risk for type 2 diabetes and cardiovascular disease.
Demonstrated via trait enrichment analysis that lifestyle and environmental exposures correlate with maternal DNA methylation variations.

Cite This Study

Srour et al. (2025) studied this question.

synapsesocial.com/papers/6a8a900a5c4c6b099dec9df3 https://doi.org/10.1186/s12967-025-07237-0

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Implication

Cohort study uncovers trimester-specific DNA methylation signatures and novel risk genes in pregnant women with gestational diabetes, indicating environmental and metabolic epigenetic influences.

Maternal DNA methylation signatures of gestational diabetes across all stages of pregnancy

Discussion

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Implication

Key Points

Cite This Study

Maternal DNA methylation signatures of gestational diabetes across all stages of pregnancy

Discussion

Member takes

Implication

Key Points

Cite This Study

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