What does this research mean for the field?

Utilizing bulky substituents to destabilize homoleptic complexation enables the highly selective construction of heteroleptic double helices, facilitating efficient chirality transfer to achiral strands and solvent-dependent helicity control. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to achieve selective chirality transfer to achiral strands using heteroleptic complexation.

June 10, 2026Open Access

Chirality Transfer to Achiral Strands and Helicity Control through Selective Heteroleptic Complexation to Double-Helical Monometallofoldamers

KMKotaro MatsumuraTokyo University of Science SMShinji Murayama YTYoshitaka TsuchidoTokyo University of Science

Key Points

The aim is to achieve selective chirality transfer to achiral strands using heteroleptic complexation.
Constructed heteroleptic double helices with bulky substituents to destabilize homoleptic complexation.
Utilized solvent conditions to optimize chirality transfer.
Examined various structural configurations of monometallofoldamers.
Successfully destabilized homoleptic complexation yielding efficient chirality transfer.
Demonstrated solvent-dependent effects on the stability of double helices.

Abstract

Highly selective construction of heteroleptic double helices was achieved by utilizing bulky substituents to destabilize homoleptic complexation. This strategic design enables efficient chirality transfer to an achiral strand and solvent-dependent...

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