Chirality Transfer to Achiral Strands and Helicity Control through Selective Heteroleptic Complexation to Double-Helical Monometallofoldamers

Q: What does this research mean for the field?

Utilizing bulky substituents to destabilize homoleptic complexation enables the highly selective construction of heteroleptic double helices, facilitating efficient chirality transfer to achiral strands and solvent-dependent helicity control. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Kotaro Matsumura; Shinji Murayama; Yoshitaka Tsuchido; Hidetoshi Kawai

doi:10.1039/d6cc01957a

January 1, 2026Chemical CommunicationsOpen Access

Chirality Transfer to Achiral Strands and Helicity Control through Selective Heteroleptic Complexation to Double-Helical Monometallofoldamers

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Key Points

The aim is to achieve selective chirality transfer to achiral strands using heteroleptic complexation.
Constructed heteroleptic double helices with bulky substituents to destabilize homoleptic complexation.
Utilized solvent conditions to optimize chirality transfer.
Examined various structural configurations of monometallofoldamers.
Successfully destabilized homoleptic complexation yielding efficient chirality transfer.
Demonstrated solvent-dependent effects on the stability of double helices.

Implication

Reveals effective chirality transfer to achiral strands through complexation, suggesting new synthesis methods.

Abstract

Highly selective construction of heteroleptic double helices was achieved by utilizing bulky substituents to destabilize homoleptic complexation. This strategic design enables efficient chirality transfer to an achiral strand and solvent-dependent...

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Cite This Study

Matsumura et al. (2026) studied this question.

synapsesocial.com/papers/6a28fe716f82f25be989bc78 https://doi.org/10.1039/d6cc01957a

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Chirality Transfer to Achiral Strands and Helicity Control through Selective Heteroleptic Complexation to Double-Helical Monometallofoldamers

Key Points

Implication

Abstract

Discussion

Cite This Study

Chirality Transfer to Achiral Strands and Helicity Control through Selective Heteroleptic Complexation to Double-Helical Monometallofoldamers

Key Points

Implication

Abstract

Discussion

Cite This Study

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