Emerging Mechanisms in Restless Legs Syndrome: Revisiting the Pathophysiology Over the Past 10 Years to Summarize Current Evidence on the Pathophysiology of Restless Legs Syndrome (RLS) Published Over the Past Decade (2015–2025) (P11-16.001)

Key Points

• This review aims to compile and summarize the evidence regarding the pathophysiology of restless legs syndrome from recent studies over the past decade.
• Reviewed studies published from 2015 to 2025
• Focused on emerging mechanisms and contributing factors to restless legs syndrome
• Analyzed data on neurotransmitters, genetic factors, and iron metabolism
• Identified key roles of neurotransmitters in RLS pathophysiology
• Highlighted genetic variations associated with increased RLS risk
• Examined the significance of iron metabolism abnormalities in etiology of RLS