Emerging Mechanisms in Restless Legs Syndrome: Revisiting the Pathophysiology Over the Past 10 Years to Summarize Current Evidence on the Pathophysiology of Restless Legs Syndrome (RLS) Published Over the Past Decade (2015–2025) (P11-16.001)

June 9, 2026Neurology

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Key Points

This review aims to compile and summarize the evidence regarding the pathophysiology of restless legs syndrome from recent studies over the past decade.
Reviewed studies published from 2015 to 2025
Focused on emerging mechanisms and contributing factors to restless legs syndrome
Analyzed data on neurotransmitters, genetic factors, and iron metabolism
Identified key roles of neurotransmitters in RLS pathophysiology
Highlighted genetic variations associated with increased RLS risk
Examined the significance of iron metabolism abnormalities in etiology of RLS

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Review summarizes the pathophysiology of restless legs syndrome from 2015 to 2025, indicating evolving insights.

To Summarize Current Evidence On The Pathophysiology of Restless Legs Syndrome (RLS) Published Over The Past Decade (2015–2025)

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Baker et al. (2026) studied this question.

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