Insulin-dependent diabetic children had a reduced increase in left ventricular size (p<0.01) and stroke volume (p<0.05) over 7 years compared to matched controls.
Cohort (n=17)
Young insulin-dependent diabetic children exhibit early echocardiographic changes such as reduced left ventricular cavity size and increased atrial ejection, suggesting the existence of a metabolically-induced cardiomyopathy independent of ischemia or hypertension.
p-value: p=<0.01
Two echo-Doppler cardiographic investigations were performed 7 years apart in 17 insulin-dependent diabetic children without hypertension or nephropathy in order to detect early signs of cardiac abnormalities in this group without ischaemic heart disease. Relative to two matched control groups, the patients had reduced increase in left ventricular size (p < 0.01) and stroke volume (p < 0.05). An initially reduced end systolic wall stress and increased fractional shortening (p < 0.003) was normalized during the 7 years. Concomitant with early signs of autonomic neuropathy and aortic stiffening, left ventricular filling changed with increased velocity during atrial contraction (p < 0.01) correlating to the decreased stroke volumes (r = -0.57, p = 0.016). These early changes could suggest left ventricular restriction but could also reflect a changed sympathetic/parasympathetic balance in diabetic children. A reduced left ventricular cavity size and increased atrial ejection has thus been described in these insulin-dependent children without hypertension, nephropathy or evidence for ischaemic heart disease, suggesting the existence of a metabolically-induced cardiomyopathy.
Gøtzsche et al. (Sun,) conducted a cohort in Insulin-dependent diabetes (n=17). Insulin-dependent diabetes vs. Matched control groups was evaluated on Increase in left ventricular size (p=<0.01). Insulin-dependent diabetic children had a reduced increase in left ventricular size (p<0.01) and stroke volume (p<0.05) over 7 years compared to matched controls.