Key result
Insulin-dependent diabetic children had a reduced increase in left ventricular size (p<0.01) and stroke volume (p<0.05) over 7 years compared to matched controls.
Population
n=17 insulin-dependent diabetic children without hypertension, nephropathy, or ischaemic heart disease
Design
Cohort
Follow-up
7 years
Authors
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May indicate early diabetic cardiomyopathy in children; hypothesis-generating and should not yet change practice or screening.
Cohort (n=17)
p-value: p=<0.01
Young insulin-dependent diabetic children exhibit early echocardiographic changes such as reduced left ventricular cavity size and increased atrial ejection, suggesting the existence of a metabolically-induced cardiomyopathy independent of ischemia or hypertension.
Gøtzsche et al. (1996) conducted a cohort in Insulin-dependent diabetes (n=17). Insulin-dependent diabetes vs. Matched control groups was evaluated on Increase in left ventricular size (p=<0.01). Insulin-dependent diabetic children had a reduced increase in left ventricular size (p<0.01) and stroke volume (p<0.05) over 7 years compared to matched controls.
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