Key result
Uncomplicated type 1 diabetes mellitus was associated with early cardiac alterations that progressed over 2 years, including a significant 7.2% reduction in left ventricular ejection fraction.
Why the study?
Does uncomplicated type 1 diabetes mellitus lead to early and progressive structural and functional cardiac alterations compared to healthy controls?
Population
56 insulin-treated, normotensive uncomplicated type 1 diabetic patients in good metabolic control, and 20…
Design
Cohort
Follow-up
23 +/- 1 months
Authors
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May support early cardiac surveillance in uncomplicated T1DM; leaves open whether progressive LVEF decline affects outcomes or warrants intervention.
Observational (n=76)
Does uncomplicated type 1 diabetes mellitus lead to early and progressive structural and functional cardiac alterations compared to healthy controls?
Young, normotensive patients with uncomplicated type 1 diabetes exhibit early structural and functional cardiac alterations that progress over a 2-year period.
Carugo et al. (2001) conducted an observational in Type 1 diabetes mellitus (n=76). Type 1 diabetes mellitus vs. Age and sex-matched healthy controls was evaluated on Left ventricular structure and function (wall thickness, diameter, ejection fraction, and diastolic function E/A). Uncomplicated type 1 diabetes mellitus was associated with early cardiac alterations that progressed over 2 years, including a significant 7.2% reduction in left ventricular ejection fraction.
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