December 29, 2015Journal of Diabetes ResearchOpen Access

Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study

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Why the study?

Does uncomplicated type 1 diabetes mellitus alter left ventricular myocardial performance early in the disease course in children and adolescents?

Population

84 children and adolescents, comprising 40 asymptomatic normotensive patients with uncomplicated type 1…

Comparison

Speckle tracking echocardiography combined with… vs Age- and gender-matched healthy controls

Design

Cross-sectional, Blinded

Authors

KHKai O. HenselCleveland Clinic FGFranziska GrimmerTechnical University of Munich MRMarkus RoskopfWitten/Herdecke University

Discussion

Member takes

Implication

Early LV changes detectable by stress speckle tracking in uncomplicated diabetes warrant validation; leaves open prognostic and therapeutic relevance.

Structured PICO

Does uncomplicated type 1 diabetes mellitus alter left ventricular myocardial performance early in the disease course in children and adolescents?

Population

84 children and adolescents, comprising 40 asymptomatic normotensive patients with uncomplicated type 1 diabetes mellitus (mean age 11.5 ± 3.1 years, mean disease duration 4.3 ± 3.5 years) and 44 age- and gender-matched healthy controls.

Intervention

Speckle tracking echocardiography combined with bicycle ergometer stress testing

Comparator

Age- and gender-matched healthy controls

Outcome

Left ventricular (LV) myocardial performance (longitudinal and circumferential strain and strain rate) at rest and during exercisesurrogate

Asymptomatic children with type 1 diabetes exhibit early signs of hyperdynamic LV contractility and subclinical systolic/diastolic impairment associated with poor glycemic control.

Cite This Study

Hensel et al. (2015) studied this question.

synapsesocial.com/papers/6a769a14232067cbf2ec217f https://doi.org/10.1155/2016/2583747

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Implication

Early LV changes detectable by stress speckle tracking in uncomplicated diabetes warrant validation; leaves open prognostic and therapeutic relevance.

Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Subclinical Alterations of Cardiac Mechanics Present Early in the Course of Pediatric Type 1 Diabetes Mellitus: A Prospective Blinded Speckle Tracking Stress Echocardiography Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider