Left univentricular pacing in patients with severe congestive heart failure significantly improved NYHA class by 40% (P<0.0001) and 6-minute walk distance by 30% (P=0.01) at 12 months.
Observational (n=22)
Does left univentricular pacing improve exercise tolerance and left ventricular function in patients with severe congestive heart failure, sinus rhythm, and left bundle-branch block?
Left univentricular pacing provides significant midterm improvements in exercise tolerance and left ventricular function in patients with severe heart failure and left bundle-branch block.
p-value: p=<0.0001
BACKGROUND: Resynchronization therapy by simultaneous pacing of the right and left ventricles has gained wide acceptance as a useful treatment for patients with severe congestive heart failure. Several short-term hemodynamic studies in humans and animals failed to demonstrate any benefit of biventricular pacing over left univentricular pacing, but long-term studies on this pacing mode are lacking. The objective of this study was to assess the outcome over a 1-year period of patients paced exclusively in the left ventricle. METHODS AND RESULTS: Clinical, angiographic, echocardiographic, and ergometric data were collected at baseline and after 12 months in 22 patients (age, 69.3+/-6.5 years) with NYHA class III or IV (10 patients), sinus rhythm, left bundle-branch block, and no bradycardia indication for pacing. After 12 months, compared with baseline values, NYHA class improved significantly by 40% (P<0.0001), 6-minute walk distance by 30% (P=0.01), peak VO2 by 26% (P=0.01), left ventricular end-diastolic diameter by 5% (P=0.02), ejection fraction by 22% (P=0.07), mitral regurgitation area by 40% (P=0.01), and norepinephrine level by 37% (P=0.04). CONCLUSIONS: In patients with severe congestive heart failure, sinus rhythm, and left bundle-branch block despite optimal pharmacological treatment, left univentricular pacing is feasible and results in significant midterm benefit in exercise tolerance and left ventricular function.
Blanc et al. (Tue,) conducted a observational in Severe congestive heart failure (n=22). Left univentricular pacing vs. Baseline was evaluated on NYHA class (p=<0.0001). Left univentricular pacing in patients with severe congestive heart failure significantly improved NYHA class by 40% (P<0.0001) and 6-minute walk distance by 30% (P=0.01) at 12 months.