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August 7, 2025International Journal of Colorectal DiseaseOpen Access

β-Sitosterol improves murine ulcerative colitis by inhibiting the expression of ribosomal proteins and the attempted polarization of type 1 macrophages

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Authors

RGRui GengYCYongqing CaoTLTe Liu

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Overview

Experimental research shows β-sitosterol improved inflammation and immune response in ulcerative colitis mice, suggesting therapeutic potential.

Key Points

  • β-Sitosterol treatment significantly reduced intestinal damage and inflammation in ulcerative colitis mice models.
  • Single-cell RNA-sequencing revealed decreased immune cell subpopulations and macrophage numbers following treatment.
  • Histopathological and flow cytometry analyses confirmed reductions in inflammatory factors like IL-1β and iNOS.
  • The findings highlight β-sitosterol's role in suppressing macrophage polarization and signaling pathways, offering insights into UC therapies.

Cite This Study

Geng et al. (2025) studied this question.

synapsesocial.com/papers/689521e49f4f1c896c4280efhttps://doi.org/10.1007/s00384-025-04974-y
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