This review explores the potential of electroencephalography biomarkers for detecting nociceptive processing in chronic pain, suggesting implications for medical advancements.
Chronic pain involves complex cortical and subcortical changes, suggesting that brain electrical activity may be a potential biomarker for nociceptive processing. Pain leaves its signature in the brain's oscillatory patterns, yet limited studies have explored the neurophysiological alterations associated with chronic pain. This review examines the pain detection method currently used in clinical settings, the potential of neurophysiological features to become brain oscillatory brain biomarkers, and their use in future medical advances.
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Ismail et al. (2025) studied this question.
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