Pilot study demonstrates Crisaborole improves vascular structure in atopic dermatitis using PAI/OCT imaging.
Atopic dermatitis (AD), a chronic inflammatory skin disorder, faces diagnostic limitations due to subjective clinical assessments. This study introduces an integrated photoacoustic imaging (PAI)/optical coherence tomography (OCT) system for noninvasive, quantitative evaluation of MC903‐induced AD‐like dermatitis in mice and Crisaborole efficacy. Multimodal imaging demonstrated Crisaborole's suppression of pathological angiogenesis (50.7% fewer vascular junctions, 23% reduced density, 47% shorter vessel length) and tissue remodeling (20% epidermal thinning, 23% signal decline), validated by histopathology. The system captured in vivo dynamic vascular network restructuring and epidermal alterations during AD progression, revealing temporal links between angiogenesis, hyperplasia, and inflammation. PAI/OCT synergistically provides complementary functional‐structural biomarkers, advancing precision diagnosis and therapy in AD models. This work pioneers real‐time monitoring of AD pathophysiology, supporting clinical translation through quantitative multiparametric characterization for tailored therapeutic strategies.
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Yang et al. (2025) studied this question.
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