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July 15, 2025

Supplementary Figure S1 from A Cyanobacteria-Derived RNA Aptamer Resensitizes Prostate Cancer to Hormone Therapy

Carlos D. Cruz-Hernández Bethany Smith Sandrine Billet Manish Thiruvalluvan Gabrielle Gonzales David M. Underhill Ekihiro Seki Shelly C. Lu Neil A. Bhowmick

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Key Points

Main finding indicates that a cyanobacteria-derived rna aptamer can resensitize prostate cancer to hormone therapy.
Key evidence reveals structural comparisons supporting the efficacy of the rna aptamer in overcoming resistance.
Approach involves aptamer modeling and analysis of crystal structure to understand interaction mechanisms.
Significance lies in potential new treatments for patients with resistant prostate cancer using rna aptamers.

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Implication

This research shows that an rna aptamer restores hormone sensitivity in prostate cancer, suggesting a novel therapeutic approach.

Abstract

Comparison of aptamer modeling and crystal structure

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Cite This Study

Cruz-Hernández et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc65e https://doi.org/10.1158/0008-5472.29568275

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from A Cyanobacteria-Derived RNA Aptamer Resensitizes Prostate Cancer to Hormone Therapy2025
2Supplementary Figure S3 from A Cyanobacteria-Derived RNA Aptamer Resensitizes Prostate Cancer to Hormone Therapy2025
3Data from A Cyanobacteria-Derived RNA Aptamer Resensitizes Prostate Cancer to Hormone Therapy2025
4Supplementary figure 10 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer2024
5Supplementary figure 10 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer2024