Supplementary Figure S5 from JAB-3312, a Potent Allosteric SHP2 Inhibitor That Enhances the Efficacy of RTK/RAS/MAPK and PD-1 Blockade Therapies

Supplementary Figure S5. JAB-3312 in combination with MEK inhibitor synergistically inhibited cancer cell growth in vitro and did not affect the weight gain of mice. A-B. Proliferation inhibition of SW620 human colon cancer cells by JAB-3312, MEKi, or their combination. C-E. The body weight change of SW620 (C), CR1554 (D), and CR3262 (E) xenograft models during the treatment of JAB-3312, MEKi, and the combination. Mean ± SEM was shown.