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July 15, 2025BiomoleculesOpen Access

Hyaluronic Acid in Immune Response

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Authors

LCLech ChrostekBCBogdan Cylwik

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Overview

This review explores how hyaluronic acid influences immune response via cytokines and signaling pathways.

Key Points

  • Hyaluronic acid is crucial in immune responses by activating intracellular signaling pathways.
  • The type of immune cells and the size of hyaluronic acid particles greatly affect its impact.
  • Increases in hyaluronic acid contribute to intensified immune reactions, such as during COVID-19.
  • Understanding hyaluronic acid's role could lead to novel approaches in treating inflammation and cancer.

Cite This Study

Chrostek et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc74fhttps://doi.org/10.3390/biom15071008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyaluronan Synthesis Is Required for IL-2-Mediated T Cell Proliferation2007 · 44 citations
  2. 2Hyaluronic Acid Receptor for Endocytosis (HARE)-mediated Endocytosis of Hyaluronan, Heparin, Dermatan Sulfate, and Acetylated Low Density Lipoprotein (AcLDL), but Not Chondroitin Sulfate Types A, C, D, or E, Activates NF-κB-regulated Gene Expression2013 · 52 citations
  3. 3Dysregulation of Pulmonary Responses in Severe COVID-192021 · 31 citations
  4. 4Signaling Properties of Hyaluronan Receptors2002 · 1,041 citations
  5. 5Binding of Hyaluronan to the Native Lymphatic Vessel Endothelial Receptor LYVE-1 Is Critically Dependent on Receptor Clustering and Hyaluronan Organization2016 · 135 citations