This review demonstrates the critical role of mitochondrial function in cancer cells' metabolism and drug resistance, highlighting the link between energy production and tumor progression.
Key Points
Cancer cells exploit mitochondrial function for survival and rapid proliferation in hostile environments.
Mitochondrial oxidative phosphorylation is crucial to tumor development, challenging the glycolysis-centric view.
Disruptions in mitochondrial dynamics lead to fragmented mitochondria associated with metastasis and drug resistance.
Investigating mitochondrial reprogramming can reveal new treatment strategies and biomarkers in cancer therapy.