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July 16, 2025Journal of Clinical MedicineOpen Access

Comparative Meta-Analysis of Survival, Risk, and Treatment Efficacy in Immunotherapy for Metastatic Melanoma Using Random-, Fixed-, and Mixed-Effects Models

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Authors

JIJelena IvetićJDJovana DedeićSMSrđan Milićević

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Overview

Meta-analysis reveals combination therapy shows improved survival in metastatic melanoma, highlighting the trade-off with higher toxicity from immune-related adverse events.

Key Points

  • Combination immunotherapy offers significant long-term clinical benefits over monotherapy in metastatic melanoma.
  • Response rates were 52.2% for combination therapy compared to 31.6% for monotherapy, indicating a substantial improvement.
  • Analysis included 14 clinical trials and over 5000 patients, using advanced statistical models to ensure robustness of the data.
  • Findings underscore the importance of comprehensive risk assessment when choosing treatment strategies for patients.

Cite This Study

Ivetić et al. (2025) studied this question.

synapsesocial.com/papers/689a02c3e6551bb0af8cc9bfhttps://doi.org/10.3390/jcm14145017
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  5. 5Seven-Year Follow-Up of the Phase III KEYNOTE-006 Study: Pembrolizumab Versus Ipilimumab in Advanced Melanoma2023 · 115 citations