Immunotherapy combined with radiotherapy in the treatment of lung cancer: a meta-analysis of therapeutic effectiveness, safety considerations, and abscopal effect

With the escalating global incidence and mortality of lung cancer, immunotherapy has achieved modest success while facing persistent challenges. The immunomodulatory effect of radiotherapy has gradually gained attention, especially the abscopal effect observed in the combination of radiotherapy and immunotherapy. Although mechanistically controversial, its clinical significance in lung cancer treatment is noteworthy. Therefore, this study aims to delve into the therapeutic differences between immunotherapy using immune checkpoint inhibitors (ICI) combined with radiotherapy (RT) and traditional immunotherapy alone, aiming to provide scientific evidence for optimizing lung cancer treatment strategies, improving patient outcomes, and enhancing survival rates. Literature searches were conducted in PubMed, Embase, Web of Science, and the Cochrane Library up to 26 March 2024. Heterogeneity, sensitivity analysis, forest plots, clipping plots, and publication bias were analysed using RevMan5.4 and Stata 12.0. This meta-analysis included 19 articles, encompassing 5109 lung cancer patients in the ICI + RT group and 4686 patients in the ICI group. Meta-analysis revealed that the progression-free survival (PFS) (HR = 0.68, 95%CI 0.62-0.75, p 0.05) or death (HR = 1.03, 95%CI 0.30-3.57, p = 1 (HR = 0.61, 95%CI 0.45-0.83, p 0.05) were only significant in males, PD-1 high expression (HR = 0.92, 95%CI 0.48-1.78, p > 0.05), PD-1 low expression (HR = 0.61, 95%CI 0.40-0.92, p 0.05) were only significant in males, PD-1 high expression (HR = 0.53, 95%CI 0.22-1.26, p > 0.05), PD-1 low expression (HR = 0.60, 95%CI 0.39-0.94, p = 1 (HR = 0.80, 95%CI 0.52-1.23, p > 0.05) were significant only in ECOG = 0. The results of this study indicate that the combination of ICI and RT significantly prolongs the Progression-Free-Survival and Overall Survival of lung cancer patients compared to the use of ICI alone, demonstrating a certain therapeutic advantage across different subgroups. This finding provides robust evidence supporting the widespread adoption of ICI+RT combination therapy for lung cancer, potentially leading to more effective treatment strategies, improved patient outcomes, and higher survival rates. https://www.crd.york.ac.uk/prospero/ , identifier CRD42024544343.