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July 22, 2025

Photocatalytic Diverse Synthesis of Transformable SF5-Scaffolds Utilizing SF6

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Authors

CJChenhui JiangHXHaoran XuYYYong Yang

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Overview

The photocatalytic method synthesizes SF5-containing scaffolds in diverse structures, highlighting its potential in drug discovery.

Key Points

  • The study introduces a novel photocatalytic method for synthesizing diverse SF5-containing scaffolds.
  • Using sulfur hexafluoride (SF6) as a reagent allows for efficient pentafluorosulfanylation under mild conditions.
  • Mechanistic studies via DFT calculations reveal a single electron reduction activation pathway for SF6.
  • This approach enhances the synthetic toolbox for fluorinated drug discovery, expanding beyond aromatic compounds.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd754https://doi.org/10.26434/chemrxiv-2025-230kr
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