July 23, 2025

A neurovascular template guides the spatial and functional compartmentalization of the adrenal gland

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The study uncovers a neurovascular mechanism guiding the spatial organization of the adrenal gland.
Semaphorin3C signaling through PlexinD1 helps establish compartment boundaries by regulating angiogenesis.
Disruption of this neurovascular signaling leads to ectopic vascularization and blurred compartment boundaries.
Understanding these mechanisms could have implications for tissue integrity and disease processes involving the adrenal gland.

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Research reveals neurovascular signaling shapes adrenal gland compartmentalization in development, implying its role in tissue integrity.

Motta et al. (2025) studied this question.

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