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July 25, 2025Pain0 citations

Optimizing Analgesics for Neuropathic Pain Through Non-Evoked Pain Assessment

Enhancing clinical translation of analgesics for neuropathic pain: a systematic review and meta-analysis on the role of non-evoked pain assessment in preclinical trials

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Authors

MHMiguel Á. HuertaPRPatricia RozaECElías Cisneros

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Overview

Systematic review and meta-analysis demonstrates that standard analgesics relieve non-evoked pain in preclinical trials, suggesting enhanced clinical translation.

Key Points

  • Standard analgesics effectively alleviated non-evoked pain in preclinical evaluations, reflecting clinical efficacy.
  • A meta-analysis of 65 studies revealed significant efficacy patterns for tricyclic antidepressants and selective serotonin reuptake inhibitors.
  • Preclinical drug testing predominantly involved traumatic nerve injury models, with effective pain relief observed.
  • Incorporating non-evoked pain assessments is crucial for improving the clinical translation of analgesic treatments.

Cite This Study

Huerta et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce009https://doi.org/10.1097/j.pain.0000000000003697
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Navigating through Neuropathic Pain: From Pathophysiology to Present and Future Treatments2026
  2. 2Neurophysiological Mechanisms of Neuropathic Pain and Their Clinical Implications2026
  3. 3FINANCIAL CONSEQUENCES OF SUBOPTIMAL DRUG THERAPY IN NEUROPATHIC PAIN TREATMENT2026
  4. 4Peripheral targets for neuropathic pain2026
  5. 5Systematic review and network meta-analysis of the effects of bioactive compounds on pain intensity and quality of life in neuropathic pain patients2025