July 28, 2025Open Access

Glucagon-like peptide-1 receptor agonists (GLP-1RA) for neuroprotection following aneurysmal subarachnoid haemorrhage (aSAH): a scoping review.

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Scoping review explores GLP-1RA's neuroprotective effects in aSAH, indicating promising potential for enhancing recovery.

GLP-1RAs show promise as neuroprotective drugs for aSAH, with the potential to reduce morbidity and mortality.
In rodent models, GLP-1RA administration improved functional recovery and mitigated adverse effects post-aSAH.
Studies indicate high expression of GLP-1R in neurons, with mechanisms involving apoptosis regulation and SIRT1 pathways.
Limited evidence suggests potential neuroprotective roles; further research is essential for efficacy and safety confirmation.

Thomas et al. (2025) studied this question.

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