Research identifies universal selection for aneuploid karyotypes in cancer, highlighting a lower mutation rate for TP53 and an increased fitness in specific combinations.
Key Points
Binary karyotypes composed of disomies and trisomies are universally selected across diverse cancers.
Karyotypes with these characteristics show a three-fold lower mutation rate of the TP53 gene.
Over 75% of karyotypes in the Mitelman database are binary, relating to a 15% higher fitness.
This discovery challenges existing frameworks of aneuploid cell classification, introducing a distinct category of karyotypes.