Abstract Nanoparticle (NP)–hydrogel hybrid materials have emerged as promising platforms for controlled drug delivery, combining the tunable chemistry of NPs (e.g., liposomes, polymeric, and inorganic NPs) with the porous, biocompatible networks of hydrogels (e.g., alginate or poly(ethylene glycol)‐based systems). These composites can encapsulate a wide range of bioactive agents—small molecules, peptides, proteins, and nucleic acids—within hydrogel matrices, guided by molecular interactions such as electrostatic forces, hydrogen bonding, and hydrophobic/hydrophilic balance. Such interactions influence both the physicochemical stability and drug release profiles of the system. This review highlights recent advances in NP–hydrogel composites, emphasizing how molecular‐level interactions shape the nanostructure, drug encapsulation, and release behavior. The enhanced mechanical strength, stimuli responsiveness, pharmacokinetics, and biological performance of these materials are also discussed. Particular focus is placed on how improved mechanistic understanding can guide the design of next‐generation hybrid systems with tunable, predictable release for biomedical applications. This review provides a comprehensive overview of NP–hydrogel hybrid materials as versatile drug delivery systems and outlines future research directions for their use in personalized therapy, targeted treatment, and broader clinical translation.
Fan et al. (2025) studied this question.