August 1, 2025Open Access

A stem cell-based platform for functional analysis of genetic variants in lung disease

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Researchers demonstrate pathogenicity of genetic variants in lung disease using an iPSC platform, highlighting its diagnostic potential.

The study identifies the function of genetic variants linked to lung disease using stem cells.
A case of primary ciliary dyskinesia was investigated with a focus on a variant in the MCIDAS gene.
Gene-editing was employed on iPSC-derived airway basal stem cells to assess variant effects.
This approach advances understanding of lung disease by linking genetic variants to clinical outcomes.

Wallman et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark