August 1, 2025Open Access

Antifungal exposure can enhance Candida glabrata pathogenesis

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Azole antifungal exposure increases virulence factors in Candida glabrata, affecting pathogenesis.
Both fluconazole and voriconazole upregulated similar virulence responses, including yapsin proteases.
Voriconazole treatment improved survival of Candida glabrata in macrophages and increased virulence in Galleria mellonella.
Effects of voriconazole involve the calcineurin and cell wall integrity pathways, suggesting new treatment strategies.

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Investigating azole effects on virulence in Candida glabrata highlights implications for host interactions.

Ribeiro et al. (2025) studied this question.

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