Recent findings reveal limitations of single-cell foundation models while advancing gene functional association predictions.
This week’s recap highlights Variant-EFFECTS for rewriting regulatory DNA to dissect and reprogram gene expression, zero-shot evaluation revealing the limitations of single-cell foundation models, EcoWeaver for large-scale prediction of gene functional associations from coevolutionary signals, and how assemblies of long-read metagenomes suffer from diverse errors.
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Stephen Turner (2025) studied this question.
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