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August 1, 2025

Supplemental Figure 3 from Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth

Hilary A. Kenny Carman Ka Man Ip Lucy Kelliher Tejas Samantaray Kasjusz Kordylewicz Rachael Hoffmann Sarah Rauch Beatrice Malacrida Sophie L.P. Skingsley Frances R. Balkwill Chiara Battistini Ugo Cavallaro Wolf R. Wiedemeyer Ernst Lengyel

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Key Points

Navitoclax and YM155, when combined with Carboplatin, significantly inhibit ovarian cancer tumor growth.
ALDH populations demonstrate increased sphere-forming capability, suggesting enhanced tumor initiation.
This approach combines Bcl-2/xL and survivin inhibition to target cancer cell survival pathways.
The findings may inform future therapies for ovarian cancer, improving treatment outcomes for patients.

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Implication

Combination therapy with navitoclax and ym155 effectively reduces tumor growth in ovarian cancer, highlighting potential treatment strategies.

Abstract

Sphere-forming capability of ALDH populations

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Cite This Study

Kenny et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02dd https://doi.org/10.1158/1535-7163.29759680

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplemental Figure 2 from Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth2025
2Supplemental Figure 1 from Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth2025
3Supplemental Figure 4 from Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth2025
4Supplemental Figure 11 from Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth2025
5Supplemental Figure 10 from Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth2025

More related papers

Supplemental Figure 9 from Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth2025
Supplemental Figure 5 from Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth2025
Supplemental Figure 14 from Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth2025