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August 5, 2025

Impact of Anxiety and Depression on Migraine-Related Disability: Results from the Headache Assessment via Digital Platform in the United States (HeAD-US) Study

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Authors

ASAdalmina SarkarEGElham GhanbarianKFKristina M. Fanning

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Overview

Cross-sectional data reveals anxiety and depression increase migraine-related disability and burden in individuals, suggesting mental health support is crucial.

Key Points

  • Coexisting anxiety and depression occur more often in chronic migraine, affecting about 30.3% of those compared to 20.0% in episodic migraine.
  • Anxiety symptoms correspond to an 8.7% increase in migraine-related disability scores, while depressive symptoms lead to a 28.4% increase.
  • Each symptom group significantly boosts the interictal burden, with increases of 11.7% for anxiety and 15.5% for depression on relevant scales.
  • This research highlights the importance of addressing mental health to lower disability and burden in migraine patients with these comorbidities.

Cite This Study

Sarkar et al. (2025) studied this question.

synapsesocial.com/papers/689a0f99e6551bb0af8d1417https://doi.org/10.1101/2025.07.14.25331532
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Study of Migraine in Headache Patients and its Association with Anxiety, Depression, and Insomnia: A Hospital-based Study2024
  2. 2Beyond headache: Anxiety and depression in migraine – A cross-sectional study from a tertiary center in South India2026
  3. 3Disability in migraine: Multicountry results from the Chronic Migraine Epidemiology and Outcomes – International (CaMEO-I) Study2024 · 13 citations
  4. 4Anxiety and depressive symptoms and migraine‐related outcomes in children and adolescents2024 · 17 citations
  5. 5Correlates of interictal burden in episodic and chronic migraine: associations with disability, sleep quality, anxiety, and depression2026