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August 6, 2025Current Issues in Molecular Biology0 citationsOpen Access

Feminization of Blood–Brain Barrier Alters Brain Transcriptome in Drosophila Males

Feminization of the Blood–Brain Barrier Changes the Brain Transcriptome of Drosophila melanogaster Males

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Authors

DDD. DavisWHWarda HashemCLChamala Lama

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Overview

Targeted expression of female-specific TraF in male Drosophila reveals altered RNA expression, indicating BBB influence on behavior.

Key Points

  • MAIN FINDING: Feminizing BBB cells in male Drosophila results in 283 altered transcripts linked to behavior.
  • KEY EVIDENCE: Comparison shows significant changes in transcripts involved in cell signaling and synaptic communication.
  • APPROACH: The study utilized RNA sequencing to analyze brain transcript changes following targeted TraF expression.
  • SIGNIFICANCE: Findings suggest a direct interaction between the BBB and brain function, impacting male courtship behavior.

Cite This Study

Davis et al. (2025) studied this question.

synapsesocial.com/papers/689a0fa0e6551bb0af8d1842https://doi.org/10.3390/cimb47080626
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