Oxidative Stress and Inflammatory Cytokines in Vitreous and Subsilicone Fluids in Patients with Rhegmatogenous Retinal Detachment.

To investigate the oxidative stress (OS) and inflammatory cytokine (IC) levels in vitreous and subsilicone fluid (SSF) in cases with rhegmatogenous retinal detachment (RRD). This prospective study included 21 cases of uncomplicated RRD. Total antioxidant status (TAS) and total oxidant status (TOS) in the samples were determined by automatic measurement method and IC levels were determined by ELISA method. In addition to routine ophthalmological examinations, flare, optic coherence tomography (OCT) and enhanced depth imaging-OCT measurements were performed during follow-up. There was a significant difference in the TOS and oxidative stress index (OSI) in SSF compared to vitreous (p < 0.05). IL-1β level was detected significantly higher in vitreous fluid (p = 0.004). When the correlation between TAS, TOS, OSI and cytokine levels in SSF and the difference in central macular thickness (CMT), choroidal thickness and flare changes measured in the 1st and 3rd month follow up of the cases after vitrectomy were evaluated, only negative correlation was observed between TOS, OSI, and CMT. OS, which has not been previously investigated in SSF, was significantly higher in this study, and our findings suggest that OS may have an initiating role in retinal damage thought to be caused by silicone oil.