Meta-analysis shows increased clinical pregnancy and live birth rates in IVF patients using frozen-thawed cleavage embryos, suggesting better outcomes than standard transfers.
In in vitro fertilization (IVF), transferring frozen-thawed blastocysts is a widely adopted practice. This meta-analysis aims to evaluate the reproductive outcomes of transferring blastocysts derived from frozen-thawed cleavage embryos (FT-CDB group) compared to direct frozen-thawed blastocyst (DFB group) transfers. We searched the following electronic databases for relevant studies: PubMed/MEDLINE, EMBASE, Scopus, and Web of Science. Studies were included if they compared the clinical and neonatal outcomes of IVF patients receiving either FT-CDB or DFB transfer with vitrification method. The protocol for this review has been registered in PROSPERO. A total of seven studies (2057 patients) were included in the analysis. Participants in the FT-CDB group demonstrated significantly higher odds of achieving clinical pregnancy (OR 1.24, 95% CI 1.03-1.49, p = 0.022, I 2 = 27%), and live birth (OR 1.31, 95% CI 1.08-1.60, p = 0.007, I 2 = 0%) compared to the DFB group. No significant differences were observed in the birth weights of infants between the groups (MD -87.05 g, 95% CI -293.77 to 119.67, p = 0.41, I 2 = 83%). Transferring blastocysts derived from frozen-thawed cleavage embryos is associated with higher odds of clinical pregnancy and live birth compared to frozen-thawed blastocyst transfers. PROSPERO number: CRD42024591620.
No takes yet. Share an insight, caveat, or question.
Tran et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: