SERS reveals distinct detection capabilities in esophageal tumor cells using CoSe2/CoS2 heterojunction, suggesting strong potential for biomedical applications.
Although surface-enhanced Raman scattering (SERS) spectroscopy is applied in biomedicine deeply, the design of new substrates for wider detection is still in demand. Crystalline-amorphous CoSe2/CoS2 heterojunction is synthesized, with high SERS performance and stability, composed of orthorhombic (o-CoSe2) and amorphous CoS2 (a-CoS2). By adjusting feed ratio, the proportion of a-CoS2 to o-CoSe2 is regulated, where CoSe2/CoS2-S50 with a 1:1 ratio demonstrates the best SERS performance due to the balance of two components. It is confirmed through experimental and simulation methods that o-CoSe2 and a-CoS2 have unique contribution, respectively: a-CoS2 has rich vacancies and a higher density of active sites, while o-CoSe2 further enriches vacancies, enhances electron delocalization and charge transfer (CT) capabilities, and reduces bandgap. Besides, CoSe2/CoS2-S50 achieves not only SERS detection of two common esophageal tumor cells (KYSE and TE) and healthy oral epithelial cells (het-1A), but also the discrimination with high sensitivity, specificity, and accuracy via machine learning (ML) analysis.
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Zhang et al. (2025) studied this question.
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