August 11, 2025RSC Chemical BiologyOpen Access

Discovery of an Exquisitely Selective WDR5 Chemical Probe Accelerated by a High-Quality DEL-ML Hit

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The chemical probe LH168 achieves high selectivity for WDR5, enhancing research into its biological role.
This probe's selectivity is confirmed with in vitro assays and shows minimal off-target effects.
Utilizing a DEL-ML approach significantly accelerated the discovery process for probe development.
The findings indicate the potential of machine learning methods in designing effective chemical probes.

Implication

Chemical probe LH168 demonstrates high selectivity for WDR5, suggesting DEL-ML technology improves probe discovery.

Abstract

Herein we present the rapid development of LH168, a potent and highly selective chemical probe for WDR5, streamlined by utilizing a DEL-ML (DNA Encoded Library - Machine Learning) hit as...

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Cite This Study

Hoffmann et al. (2025) studied this question.

synapsesocial.com/papers/68a35eeb0a429f7973327e43 https://doi.org/10.1039/d5cb00109a

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Implication

Chemical probe LH168 demonstrates high selectivity for WDR5, suggesting DEL-ML technology improves probe discovery.

Abstract

Herein we present the rapid development of LH168, a potent and highly selective chemical probe for WDR5, streamlined by utilizing a DEL-ML (DNA Encoded Library - Machine Learning) hit as...

Discovery of an Exquisitely Selective WDR5 Chemical Probe Accelerated by a High-Quality DEL-ML Hit

Key Points

Implication

Abstract

Discussion

Cite This Study

Discovery of an Exquisitely Selective WDR5 Chemical Probe Accelerated by a High-Quality DEL-ML Hit

Key Points

Implication

Abstract

Discussion

Cite This Study

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