Amyloidosis of the Seminal Vesicle, Ejaculatory Duct, vas Deferens and Epididymis an Update

It has been iterated that cases of primary amyloidosis of the prostate gland, seminal vesicles, vas deferens, epididymis as well as ejaculatory ducts are not common and in view of this pathologists, urologists, and oncologists should have high index of suspicion for the aforementioned four lesions Primary amyloidosis of the prostate gland, seminal vesicles, epididymis and ejaculatory ducts had tended to be diagnosed incidentally based upon microscopy histopathology examination of specimens of the prostate gland, seminal vesicle and ejaculatory duct and epididymis obtained pursuant to the undertaking or prostatectomy or during examination of specimens of the prostate gland that had been obtained from prostate biopsies taken during the assessment of the prostate gland to exclude prostate cancer related to raised levels of serum prostate specific antigen (PSA) or abnormal digital rectal examination findings of the prostate gland and or seminal vesicle or at times radiology imaging of the prostate gland and pelvis might demonstrate features of the prostate gland, seminal vesicle and ejaculatory duct or epididymis area that look abnormal or irregular which would necessitate the undertaking of radiology image-guided biopsies of the lesion. Majority of cases of primary amyloidosis of the prostate gland, seminal vesicle and ejaculatory duct and epididymis tend to be asymptomatic but some cases of primary amyloidosis of the seminal vesicle vas deferens, ejaculatory duct might manifest with blood within the semen of an individual. Some cases of amyloidosis of the prostate gland, seminal vesicles, vas deferens epididymis and ejaculatory ducts had been diagnosed contemporaneously in association with areas of adenocarcinoma of the prostate gland. Pathology examination of areas of the prostate gland, seminal vesicles, and ejaculatory ducts vas deferens and epididymis tends to depict or demonstrate amorphous, pale eosinophilic material which is often associated with cracks from processing of the biopsy or prostatectomy specimen Specimens of amyloid within the prostate gland, seminal vesicle, vas deferens, epididymis and ejaculatory duct exhibit immunohistochemical staining features with Congo Red by the demonstration of green birefringence upon polarised microscopy. Amyloidosis of the prostate gland, seminal vesicles, vas deferens epididymis and ejaculatory duct tends to simulate upon radiology imaging undertaken by magnetic resonance imaging (MRI) scan features of prostate cancer invading the seminal vesicle, vas deferens, epididymis or ejaculatory duct, carcinoma of the urinary bladder invading the seminal vesicle, vas deference, epididymis as well as ejaculatory duct, and adenocarcinoma of the rectum invading the seminal vesicle, epididymis, vas deference and ejaculatory duct as well as a rare case of primary adenocarcinoma of seminal vesicle. It has been iterated that therapy of primary amyloidosis of the prostate gland, seminal vesicles and ejaculatory does depend upon the underlying condition.