Synaptophysin in Neurons of the Cingulate Cortex of the Rat Brain in Cholestasis

Background. The study of synaptophysin immunoreactivity in axodendritic and axosomatic synapses of neurons in the small-cell and large-cell layers of the cingulate cortex in cholestasis will help to understand their functional state in this pathology. Aim. To study the immunoreactivity of synaptophysin in axodendritic and axosomatic synapses of neurons in the cingulate cortex of the rat brain. Material and methods. Neurons of the parvocellular and magnocellular layers of the anterior cingulate cortex of the rat brain were studied at different times after ligation/transection of the common bile duct or sham surgery (control group). Histological, immunohistochemical, morphometric, and statistical methods were used. Results. At the peak of cholestasis (days 10 and 20), the content of synaptophysin in the synapses of neurons of the cingulate cortex in rats significantly decreased. In the long-term period (days 45 and 90 after the operation), after cholestasis was eliminated, the content of synaptophysin in the cingulate cortex was normalized. Conclusions. The neurons of the parvocellular and magnocellular layers of the anterior cingulate cortex have high synaptic plasticity.