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August 11, 2025Journal of Allergy and Clinical ImmunologyOpen Access

IL-18 in atopic dermatitis - A multifaceted driver of skin inflammation

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Authors

LBLukas BählerSSStefanie SchärliFLFabian Luther

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Overview

Review highlights IL-18's impact on atopic dermatitis severity and immune responses in patients, suggesting therapeutic potential.

Key Points

  • Elevated IL-18 levels correlate with increased severity of atopic dermatitis, indicating its role in skin inflammation.
  • Increased IL-18 in skin and serum impact type 2 immune response negatively affecting barrier functions.
  • Assessment using mouse models shows that targeting IL-18 alleviates symptoms of atopic dermatitis effectively.
  • The findings may enable new treatment strategies focusing on IL-18 for managing atopic dermatitis effectively.

Cite This Study

Bähler et al. (2025) studied this question.

synapsesocial.com/papers/68a360e70a429f797332967chttps://doi.org/10.1016/j.jaci.2025.07.025
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