Assessment of Patient‐Reported Outcome Measures in Patients Undergoing Bowel Preparation With Mannitol for Colonoscopy: The SATISFACTION Study

Background Bowel preparation for colonoscopy causes significant discomfort to patients. Large volumes, unpleasant taste, and split‐dosing are the main disadvantages of most laxatives. Oral mannitol could be an attractive option because it acts quickly, requires low volumes, and has a pleasant taste. Aims A Phase III study (SATISFACTION) compared oral mannitol with polyethylene glycol‐ascorbate (PEG‐ADC). This post hoc analysis investigated the effects on patient‐reported outcomes (PROMs), mainly concerning the perception of using the preparations. Methods The SATISFACTION Phase III study was an international, multicenter, randomized (1:1), parallel‐group, endoscopist‐blinded, non‐inferiority trial. Taste of preparations, ease of use, and willingness to repeat the preparation with the same product were scored and assessed by the patients. Results Bowel preparation with oral mannitol resulted in a better patient satisfaction profile for all PROMs evaluated. Conclusion Oral mannitol for bowel preparation achieved high patient satisfaction and might be a valuable option for colonoscopy. Trial Registration ClinicalTrials.gov ( https://clinicaltrials.gov/ct2/show/NCT04759885 )