Genome-wide DNA methylation reveals neuroimmune and fibrotic pathway dysregulation in prurigo nodularis, suggesting new therapy targets.
This study integrates genome-wide DNA methylation and transcriptomic profiling to reveal key dysregulated pathways in prurigo nodularis (PN). Lesional PN skin exhibits distinct epigenetic reprogramming that activates neuroimmune, fibrotic, and inflammatory gene networks, uncovering potential targets for precision therapies in chronic pruritic skin disease.
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Shahsavari et al. (2025) studied this question.
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