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August 13, 2025TrialsOpen Access

Community and Universal Testing for TB among close contacts of microbiologically confirmed pulmonary TB patients in two high TB burden countries: a protocol for a pragmatic cluster-randomised control trial

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Authors

MMMaureen MoyoTNThobani NtshiqaYHYohhei Hamada

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Overview

Cluster-randomised trial evaluates universal TB testing effectiveness in household contacts, suggesting improved case detection and preventive strategies.

Key Points

  • Universal TB testing significantly improves TB detection compared to traditional symptom screening.
  • The pragmatic trial involves drug-sensitive TB index patients and their household contacts randomly assigned to two testing methods.
  • Microbiological confirmation within six weeks of diagnosis is crucial for enrolling TB index patients into the trial.
  • Findings may inform cost-effective TB strategies in high-burden countries, enhancing public health responses.

Cite This Study

Moyo et al. (2025) studied this question.

synapsesocial.com/papers/68a363490a429f797332a15fhttps://doi.org/10.1186/s13063-025-08978-5
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